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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK1
All Species:
24.55
Human Site:
S558
Identified Species:
45
UniProt:
Q9P0L2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P0L2
NP_061120.3
795
89003
S558
H
Q
K
S
M
S
T
S
G
H
P
I
K
V
T
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
G559
Q
K
S
M
S
T
S
G
H
P
I
K
V
T
L
Rhesus Macaque
Macaca mulatta
XP_001115611
778
86745
S543
S
V
H
P
N
K
A
S
G
L
P
P
T
E
S
Dog
Lupus familis
XP_536123
782
87409
S545
H
Q
K
S
M
S
T
S
G
H
P
I
K
V
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8VHJ5
795
88528
S558
H
Q
K
S
M
S
T
S
G
H
P
I
K
V
T
Rat
Rattus norvegicus
O08678
793
88216
S558
H
Q
K
S
M
S
T
S
G
H
P
I
K
V
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
S556
H
Q
K
S
M
S
A
S
G
H
P
I
K
V
T
Chicken
Gallus gallus
Q9IA88
798
88848
S532
A
G
Q
V
M
T
G
S
P
A
T
A
R
M
T
Frog
Xenopus laevis
NP_001085126
792
88624
I558
M
S
A
S
G
H
P
I
K
V
T
L
P
T
I
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
S686
H
G
E
N
Q
P
S
S
H
L
T
Y
Q
L
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
S955
S
S
Y
Q
I
P
T
S
T
A
V
N
V
T
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
D286
Y
L
A
V
S
P
P
D
T
V
E
Q
A
K
K
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
D407
K
S
V
S
D
E
L
D
T
F
L
S
Q
S
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
68.9
95.9
N.A.
94.9
94.3
N.A.
92.8
30.4
88.6
27.8
N.A.
N.A.
N.A.
40.7
N.A.
Protein Similarity:
100
99.3
80.2
96.8
N.A.
97.3
96.9
N.A.
95.9
51.3
94.2
44
N.A.
N.A.
N.A.
51
N.A.
P-Site Identity:
100
0
20
100
N.A.
100
100
N.A.
93.3
20
6.6
13.3
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
20
26.6
100
N.A.
100
100
N.A.
93.3
46.6
13.3
46.6
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.9
28
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.4
46.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
16
0
0
0
16
0
0
16
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
16
0
0
0
0
0
0
0
% D
% Glu:
0
0
8
0
0
8
0
0
0
0
8
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
16
0
0
8
0
8
8
47
0
0
0
0
0
0
% G
% His:
47
0
8
0
0
8
0
0
16
39
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
8
0
0
8
39
0
0
8
% I
% Lys:
8
8
39
0
0
8
0
0
8
0
0
8
39
8
8
% K
% Leu:
0
8
0
0
0
0
8
0
0
16
8
8
0
8
8
% L
% Met:
8
0
0
8
47
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
8
8
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
8
0
24
16
0
8
8
47
8
8
0
8
% P
% Gln:
8
39
8
8
8
0
0
0
0
0
0
8
16
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
16
24
8
54
16
39
16
70
0
0
0
8
0
8
16
% S
% Thr:
0
0
0
0
0
16
39
0
24
0
24
0
8
24
47
% T
% Val:
0
8
8
16
0
0
0
0
0
16
8
0
16
39
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _